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Endocrine research

Long-acting CJC-1295: hormone measurements are not clinical outcomes

Two early controlled trials examined exposure, growth hormone and IGF-I in healthy adults.

Clinical trialPaper year: 2006CJC-1295 with DAC

01 / DESIGN

What was studied?

Two randomized, double-blind, placebo-controlled dose-escalation studies followed healthy adults for 28 or 49 days. Investigators measured circulating CJC-1295, growth hormone and IGF-I rather than disease recovery or functional performance.

02 / FINDINGS

What did the researchers report?

The long-acting analogue produced sustained increases in growth hormone and IGF-I. Repeated exposure showed accumulation in the measured hormonal response. The investigators reported no serious adverse reactions in these short studies.

03 / LIMITS

How should it be interpreted?

These findings concern a long-acting, albumin-binding analogue, not a no-DAC material or an ipamorelin blend. Short-term tolerability in selected adults cannot establish long-term safety, effectiveness for a disease, or equivalence of commercial research materials.

Voltera Peptide editorial reading note. Based on the linked source record. Methods and corrections.

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