Preclinical study
GHK-Cu in colitis models: testing a proposed SIRT1/STAT3 link
Mouse colitis experiments were combined with macrophage-epithelial cocultures, protein measurements and STAT3 silencing.
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Preclinical study
GHK-hyaluronan conjugates: a modified material is a different research question
New copper-binding conjugates were studied in vitro; they were not ordinary GHK-Cu vials.
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GLORY-1: moving from phase 2 to a larger mazdutide trial
A phase 3 study extended the evidence in Chinese adults with overweight or obesity.
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Kisspeptin-10 and cerebral aneurysm models: receptor dependence
Patient biomarker observations were combined with mouse receptor-knockout experiments and human endothelial-cell assays.
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Peptide tablets: processing can change stability as well as release
Model insulin compacts combined two permeation enhancers with excipients and underwent compression, release and accelerated-storage testing.
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REDEFINE 2: a combination trial in type 2 diabetes
The population and comparison define what this combination trial can tell us.
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Semax and a derivative in an amyloid mouse model
Transgenic mice were assessed with behavioral tasks and brain histology after exposure to Semax or a derivative.
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Semax and copper-bound amyloid: a chemical mechanism study
Biochemical assays and a neuroblastoma-cell model examined copper interactions, reactive oxygen production and amyloid-related toxicity.
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Semax and neuronal calcium: effects differed by brain region
Rat hippocampal and cerebellar slices were used to measure spontaneous and acid-triggered intracellular calcium responses.
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Semax in spinal injury: testing lysosomal and ubiquitination pathways
A female-mouse spinal-injury model was combined with neuronal-cell experiments, sequencing and target-perturbation studies.
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SUMMIT: reading a composite heart-failure endpoint
The trial studied people with obesity and HFpEF, using clinical events and health-status measures.
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SURMOUNT-1 follow-up: diabetes progression over three years
A longer analysis focused on participants who had both obesity and prediabetes.
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