Clinical trial
Mazdutide in a US phase 2 trial: population and estimand
A multicenter randomized study evaluated mazdutide against placebo in US adults with obesity or overweight without diabetes.
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Clinical trial
Mazdutide monotherapy: placebo-controlled glycemic outcomes
Adults with diabetes inadequately controlled through diet and exercise were randomized to mazdutide or placebo for the controlled phase of a phase 3 trial.
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Mazdutide versus dulaglutide: why the active comparator matters
A randomized phase 3 trial compared mazdutide with a specified dulaglutide regimen in adults receiving background oral diabetes medicines.
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MOTS-c and adrenal metabolism: preparation without hormone stimulation
Rat adrenal tissue was examined after a short continuous exposure, using hormone assays, tissue staining and gene-expression methods.
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MOTS-c and cardiac inflammasomes in diabetic rats
A diet-plus-chemical diabetes model was used to examine systemic markers and inflammasome-associated proteins in rat hearts.
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MOTS-c and host defense: mitochondrial signaling beyond metabolism
Experiments combined bacterial membrane assays, human monocytes, mouse-cell differentiation and an acute mouse infection model.
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MOTS-c in adolescent PCOS: a study without a clear group difference
Investigators compared serum measurements and one mitochondrial variant in adolescents with polycystic ovary syndrome and controls.
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MOTS-c in cancer cachexia: muscle preservation was incomplete
Researchers studied differentiated muscle cells and mice bearing Colon-26 tumors, measuring muscle mass and metabolic signaling.
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MOTS-c in dialysis: the sample compartment changes the story
A pilot study measured MOTS-c in serum, urine and dialysate from thirty-two stable peritoneal-dialysis patients.
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MOTS-c in stromal cells: metabolic activation did not restore repair
Human adipose-derived stromal cells were studied in culture and after pretreatment before use in a mouse kidney-injury model.
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Oral glutathione formulations: exposure differences in a pilot crossover study
Fourteen healthy adults participated in a blinded crossover comparison of defined oral formulations, followed by a short single-arm safety phase.
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REIMAGINE 1: combination treatment in early type 2 diabetes
A blinded phase 3 study compared cagrilintide-semaglutide with placebo over forty weeks in adults inadequately controlled through diet and exercise.
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