Preclinical study
BPC-157 and TB-500 in rat tendon repair: no clear combination advantage
A small randomized rat tendon-transection study compared control, individual interventions and their combination over four weeks.
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Analytical study
BPC-157 chitosan hydrogel: material characterization before efficacy
A composite hydrogel was characterized using microscopy, spectroscopy, release testing and selected compatibility and antibacterial assays.
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BPC-157 hybrid analogs: an enzyme-screening result
An enzyme assay and modeling compared BPC-157 with two designed hybrid peptides for acetylcholinesterase inhibition.
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BPC-157 in human arterial tissue: ex-vivo is not a clinical trial
Residual artery segments from surgery were studied as isolated rings, with endothelial removal and nitric-oxide-pathway inhibition.
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BPC-157 in limb reperfusion injury: local tissue endpoints
A small rat model used controlled arterial occlusion and short reperfusion, followed by oxidative, gene-expression and muscle-histology measurements.
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Cagrilintide brainstem atlas: receptor expression versus function
A cross-species cell atlas was combined with spatial mapping and functional experiments in rat brainstem populations.
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Cagrilintide pharmacokinetics in renal and hepatic impairment
Two small single-dose studies compared exposure across groups with different levels of renal or hepatic function.
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Circulating MOTS-c after weight loss: a small longitudinal study
Researchers compared lean and obese adults, with a small subset measured again after bariatric surgery.
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Elamipretide and muscle mechanics in an HFpEF rat model
Female rats modeling obesity-related heart failure were studied using muscle-force tests, mitochondrial measurements and tissue analyses.
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Elamipretide in trifunctional-protein deficiency: mixed endpoint responses
Genetically deficient mice and patient-derived fibroblasts were used to test mitochondrial function and responses to physiological challenges.
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ESTATE: what a single-arm tirzepatide study can show
The retrospective ESTATE study examined twenty-four-week changes in eighty-eight Japanese adults with type 2 diabetes in routine practice.
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FLOW safety analysis: why kidney-function subgroups matter
A prespecified analysis grouped FLOW participants with diabetes and chronic kidney disease by their baseline kidney function.
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